Publications
Google Scholar
Commentaries and Outreach
Translational genomics
Hall and Castellano
Dawnn: single-cell differential abundance with neural networks
bioRxiv
Bea-Mascato et al.
bioRxiv
Puigdevall et al.
Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment
Cell Genomics, 3, 100280 (2023)
Morfopoulou et al.
Genomic investigations of acute hepatitis of unknown aetiology in children
Nature, 617, 564–573 (2023)
Jayarajan et al.
Cells, 12, 346 (2023)
Michelozzi et al.
Blood Advances, 7, 1725–1738 (2023)
Wilkinson et al.
Annals of the Rheumatic Diseases, 82, 658-669 (2023)
Aggarwal et al. (including COG-UK).
The role of genomics in understanding COVID-19 outbreaks in long term care facilities
The Lancet Microbe, 3, e151-e158 (2022)
Snell et al. (including COG-UK).
Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 transmission identifies community social distancing as the dominant intervention reducing outbreaks
Clinical Microbiology and Infection, 28, 93–100 (2022)
Sánchez-Corrales, Pohle, Castellano and Giustacchini
Taming Cell-to-Cell Heterogeneity in Acute Myeloid Leukaemia With Machine Learning
Frontiers in Oncology, 11, 1411 (2021)
Lythgoe et al. (including COG-UK)
SARS-CoV-2 within host diversity and transmission
Science, 372, eabg0821 (2021)
Parker et al. (including COG-UK)
Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data
Genome research, 31, 645-658 (2021)
Stirrup et al. (including COG-UK).
Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data
Elife, 10, e65828 (2021)
Thomson et al. (including COG-UK)
Cell, 184, 1171-1187 (2021)
Hosie et al. (including COG-UK). Detection of SARS‐CoV‐2 in respiratory samples from cats in the UK associated with human‐to‐cat transmission.
Veterinary Record, 188, 8 (2021)
du Plessis et al. (including COG-UK)
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
Science, 371, 708-712 (2021)
Volz et al. (including COG-UK)
Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity
Cell, 184, 64-75 (2021)
O'Toole et al. (including COG-UK)
Tracking the international spread of SARS-CoV-2 lineages B. 1.1. 7 and B. 1.351/501Y-V2 with grinch
Wellcome open research, 6 (2021)
Page et al. (including COG-UK)
Microbial genomics, 7 (2021)
Da Silva et al. (including COG-UK)
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
Nature Microbiology, 6, 112-122 (2021)
The COVID-19 Genomics UK consortium (COG-UK)
An integrated national scale SARS-CoV-2 genomic surveillance network
The Lancet Microbe, 1, e99–e100 (2020)
Ancient genomics
Martin, Jay, Castellano and Slatkin
Molecular Ecology, 26, 4145-4157 (2017)
De Manuel et al.
Chimpanzee genomic diversity reveals ancient admixture with bonobos
Science, 354, 477-481 (2016)
Mendez, Poznik, Castellano and Bustamante
The divergence of Neandertal and modern human Y chromosomes
The American Journal of Human Genetics, 98, 728-734 (2016)
Kuhlwilm et al.
Ancient gene flow from early modern humans into Eastern Neanderthals
Nature, 530, 429-433 (2016)
Lazaridis et al.
Ancient human genomes suggest three ancestral populations for present-day Europeans
Nature, 513, 409-413 (2014)
Castellano et al.
Patterns of coding variation in the complete exomes of three Neandertals
PNAS, 111, 6666-6671 (2014)
Fu et al.
A revised timescale for human evolution based on ancient mitochondrial genomes
Current Biology, 23, 553-559 (2013)
Micronutrient genomics
Rees et al.
Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase
bioRxiv
Sarangi et al.
Distinct Patterns of Selection in Selenium-Dependent Genes between Land and Aquatic Vertebrates
Molecular Biology and Evolution, 35, 1744-1756 (2018)
The genomics of selenium: Its past, present and future
Biochimica et Biophysica Acta, 1862, 2427-2432 (2018).
Genetic adaptation and Selenium uptake in vertebrates.
In Encyclopedia of the Life Sciences. Wiley (2018)
Castellano.
Selenium strikes back at fungi
Nature Microbiology, 4, 726-727 (2018)
Selenoprotein Gene Nomenclature
The Journal of Biological Chemistry, 291, 24036-24040 (2016)
The role of selenium in human evolution
In D. Hatfield and V. Gladyshev (Eds.), Selenium: Its molecular biology and role in human health (4th ed., pp. 59-71). Springer (2016)
Genetic adaptation to levels of dietary selenium in recent human history
Molecular Biology and Evolution, 32, 1507-1518 (2015)
SelenoDB 2.0: Annotation of selenoprotein genes in animals and their genetic diversity in humans
Nucleic Acids Research, 42, D437-D443 (2014)
White and Castellano
Evolutionary basis for the use of selenocysteine
In DL Hatfield, MJ Berry and VN Gladyshev (Eds.), Selenium: Its Molecular Biology and Role in Human Health (3, pp. 85-93). New York. Springer (2012)
Castellano
On the unique function of selenocysteine - insights from the evolution of selenoproteins
Biochimica et Biophysica Acta, 1790, 1463-1470 (2009) - In special issue on selenoprotein expression and function
Castellano et al.
Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins
Molecular Biology and Evolution, 26, 2031-2040 (2009)
Castellano, Gladyshev, Guigó and Berry
SelenoDB 1.0: A database of selenoprotein genes, proteins and SECIS elements
Nucleic Acids Research, 36, D332-D338 (2008)
Castellano
Reader response - A critical assessment of PLoS Genetics, 2, e3 (2006). PLoS Genetics (2006)
PNAS, 102, 16188-16193 (2005)
Taskov et al.
The use of the selenocysteine insertion system to decode one codon in an animal genome?
Nucleic Acids Research, 33, 2227-2238 (2005)
International Chicken Genome Sequencing Consortium
Nature, 432, 695-716 (2004)
Jaillon et al.
Nature, 431, 946-957 (2004)
Castellano
Towards the characterization of the eukaryotic selenoproteome: a computational approach
PhD Thesis (2004)
Castellano et al.
EMBO Reports, 5, 71-77 (2004)
Kryukov et al.
Characterization of mammalian selenoproteomes
Science, 300, 1439-1443 (2003)
Castellano et al.
In silico identification of novel selenoproteins in the Drosophila melanogaster genome
EMBO Reports, 2, 697-702 (2001)
Computational genomics
Abril and Castellano
Genome Annotation
In Encyclopedia of Bioinformatics and Computational Biology
Elsevier (2018)
Population genomics
Rees, Castellano and Andrés
The Genomics of Human Local Adaptation
Trends in Genetics, 36, 415-428 (2018)