Hall and Castellano
Dawnn: single-cell differential abundance with neural networks
Bea-Mascato et al.
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes
Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment
Jayarajan et al.
Short-term keratinocyte Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth while preserving stem cell characteristics
Cells, in press
Morfopoulou et al.
Genomic investigations of acute hepatitis of unknown aetiology in children
Nature, in press
Wilkinson et al.
CD14+ monocyte-derived oxidised mitochondrial DNA amplifies the inflammatory interferon type 1 signature in Juvenile Dermatomyositis
Annals of the Rheumatic Diseases, in press
Michelozzi et al.
Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype
Blood Advances, in press
Aggarwal et al. (including COG-UK).
The role of genomics in understanding COVID-19 outbreaks in long term care facilities
The Lancet Microbe, 3, e151-e158 (2022)
Snell et al. (including COG-UK).
Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 transmission identifies community social distancing as the dominant intervention reducing outbreaks
Clinical Microbiology and Infection, 28, 93–100 (2022)
Sánchez-Corrales, Pohle, Castellano and Giustacchini
Taming Cell-to-Cell Heterogeneity in Acute Myeloid Leukaemia With Machine Learning
Frontiers in Oncology, 11, 1411 (2021)
Lythgoe et al. (including COG-UK)
SARS-CoV-2 within host diversity and transmission
Science, 372, eabg0821 (2021)
Parker et al. (including COG-UK)
Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data
Genome research, 31, 645-658 (2021)
Stirrup et al. (including COG-UK).
Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data
Elife, 10, e65828 (2021)
Thomson et al. (including COG-UK)
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Cell, 184, 1171-1187 (2021)
Hosie et al. (including COG-UK). Detection of SARS‐CoV‐2 in respiratory samples from cats in the UK associated with human‐to‐cat transmission.
Veterinary Record, 188, 8 (2021)
du Plessis et al. (including COG-UK)
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
Science, 371, 708-712 (2021)
Volz et al. (including COG-UK)
Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity
Cell, 184, 64-75 (2021)
O'Toole et al. (including COG-UK)
Tracking the international spread of SARS-CoV-2 lineages B. 1.1. 7 and B. 1.351/501Y-V2 with grinch
Wellcome open research, 6 (2021)
Page et al. (including COG-UK)
Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management
Microbial genomics, 7 (2021)
Da Silva et al. (including COG-UK)
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
Nature Microbiology, 6, 112-122 (2021)
The COVID-19 Genomics UK consortium (COG-UK)
An integrated national scale SARS-CoV-2 genomic surveillance network
The Lancet Microbe, 1, e99–e100 (2020)
Martin, Jay, Castellano and Slatkin
Determination of genetic relatedness from low-coverage human genome sequences using pedigree simulations
Molecular Ecology, 26, 4145-4157 (2017)
De Manuel et al.
Chimpanzee genomic diversity reveals ancient admixture with bonobos
Science, 354, 477-481 (2016)
Mendez, Poznik, Castellano and Bustamante
The divergence of Neandertal and modern human Y chromosomes
The American Journal of Human Genetics, 98, 728-734 (2016)
Kuhlwilm et al.
Ancient gene flow from early modern humans into Eastern Neanderthals
Nature, 530, 429-433 (2016)
Lazaridis et al.
Ancient human genomes suggest three ancestral populations for present-day Europeans
Nature, 513, 409-413 (2014)
Castellano et al.
Patterns of coding variation in the complete exomes of three Neandertals
PNAS, 111, 6666-6671 (2014)
Fu et al.
A revised timescale for human evolution based on ancient mitochondrial genomes
Current Biology, 23, 553-559 (2013)
Rees et al.
Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase
Sarangi et al.
Distinct Patterns of Selection in Selenium-Dependent Genes between Land and Aquatic Vertebrates
Molecular Biology and Evolution, 35, 1744-1756 (2018)
The genomics of selenium: Its past, present and future
Biochimica et Biophysica Acta, 1862, 2427-2432 (2018).
Genetic adaptation and Selenium uptake in vertebrates.
In Encyclopedia of the Life Sciences. Wiley (2018)
Selenium strikes back at fungi
Nature Microbiology, 4, 726-727 (2018)
Selenoprotein Gene Nomenclature
The Journal of Biological Chemistry, 291, 24036-24040 (2016)
The role of selenium in human evolution
In D. Hatfield and V. Gladyshev (Eds.), Selenium: Its molecular biology and role in human health (4th ed., pp. 59-71). Springer (2016)
Genetic adaptation to levels of dietary selenium in recent human history
Molecular Biology and Evolution, 32, 1507-1518 (2015)
SelenoDB 2.0: Annotation of selenoprotein genes in animals and their genetic diversity in humans
Nucleic Acids Research, 42, D437-D443 (2014)
White and Castellano
Evolutionary basis for the use of selenocysteine
In DL Hatfield, MJ Berry and VN Gladyshev (Eds.), Selenium: Its Molecular Biology and Role in Human Health (3, pp. 85-93). New York. Springer (2012)
On the unique function of selenocysteine - insights from the evolution of selenoproteins
Biochimica et Biophysica Acta, 1790, 1463-1470 (2009) - In special issue on selenoprotein expression and function
Castellano et al.
Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins
Molecular Biology and Evolution, 26, 2031-2040 (2009)
Castellano, Gladyshev, Guigó and Berry
SelenoDB 1.0: A database of selenoprotein genes, proteins and SECIS elements
Nucleic Acids Research, 36, D332-D338 (2008)
Little biological and statistical support for hundreds of selenoproteins in mouse pseudo-messenger RNAs
Reader response - A critical assessment of PLoS Genetics, 2, e3 (2006). PLoS Genetics (2006)
Diversity and functional plasticity of eukaryotic selenoproteins: Identification and characterization of the SelJ family
PNAS, 102, 16188-16193 (2005)
Taskov et al.
The use of the selenocysteine insertion system to decode one codon in an animal genome?
Nucleic Acids Research, 33, 2227-2238 (2005)
International Chicken Genome Sequencing Consortium
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
Nature, 432, 695-716 (2004)
Jaillon et al.
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
Nature, 431, 946-957 (2004)
Towards the characterization of the eukaryotic selenoproteome: a computational approach
PhD Thesis (2004)
Castellano et al.
Reconsidering the evolution of eukaryotic selenoproteins: A novel nonmammalian family with scattered phylogenetic distribution
EMBO Reports, 5, 71-77 (2004)
Kryukov et al.
Characterization of mammalian selenoproteomes
Science, 300, 1439-1443 (2003)
Castellano et al.
In silico identification of novel selenoproteins in the Drosophila melanogaster genome
EMBO Reports, 2, 697-702 (2001)
Abril and Castellano
In Encyclopedia of Bioinformatics and Computational Biology
Rees, Castellano and Andrés
The Genomics of Human Local Adaptation
Trends in Genetics, 36, 415-428 (2018)